 The Depo shot is quite the concoction of dangerous chemicals. Here’s what you need to know. There are seven listed ingredients plus "when necessary, pH is adjusted with sodium hydroxide or hydrochloric acid, or both.” – adding these two, makes nine. Of these possible nine ingredients, only one of these things isn’t an irritant, health hazard, flammable, corrosive and or acutely toxic. When I was doing research for this piece, I double and triple checked the spellings of the chemical names, I couldn't believe what I was reading. I kept thinking out loud “there’s got to be a mistake here, there’s NO WAY this is actually in the shot.” But, ingredient after ingredient the spelling was right, these are the terrifying chemicals that make up a Depo shot. The ingredients list can be found here:
For all the things that have a glossary of terms index, having this for product information like the Depo shot, where using the drug comes with so much risk would be so helpful – don’t you think? How many of us even saw the product monograph or FDA highlights of prescribing information before taking Depo? Those that did, how many breezed through it because we simply couldn’t understand what we were reading? Often without proper consult from prescribing doctors too, so many of us took this shot blindly. This is what the FDA Highlights of Prescribing Information document lists as Depo’s ingredients: Medroxyprogesterone Acetate 150 mg Polyethylene Glycol 3350 28.9 mg Polysorbate 80 2.41 mg Sodium Chloride 8.68 mg Methylparaben 1.37 mg Propylparaben 0.150 mg Water for injection quantity sufficient When necessary, pH is adjusted with Sodium Hydroxide or Hydrochloric Acid, or both. For each of these ingredients I’ve listed the amount that’s in a single shot, its drug class, chemical safety and safety signal information. I’ve also broken down what each drug class classification means and then discussed the ingredient itself. Grab a warm beverage and cozy in – we have a lot to cover. Medroxyprogesterone Acetate Amount 150 mg Drug Class Antineoplastics, Synthetic Hormones, Progestins, Antigonadotropin, Steroidal Antiandrogen Chemical Safety IRRITANT, HEALTH HAZARD Safety Signal WARNING, DANGER Drug Class Breakdown Antineoplastics The Center for Disease Control and Prevention (CDC) says this about Antineoplastics: “Antineoplastic drugs are medications used to treat cancer. Antineoplastic drugs are also called anticancer, chemotherapy, chemo, cytotoxic, or hazardous drugs. We know that cancer patients who are taking antineoplastic drugs have an increased risk of infertility. If they are treated during pregnancy, these patients have an increased risk of miscarriage or having a child with a birth defect. People who work with these drugs have also been found to have an increased risk of having a miscarriage or a child with a birth defect. Antineoplastic drugs work by targeting and killing rapidly dividing cancerous cells, but they can also be harmful to healthy dividing cells, including the cells of a developing baby.” https://www.cdc.gov/niosh/topics/hazdrug/antineoplastic.html Synthetic Hormones According to Dr. Jeff Butterworth from happyhealthyou.com, synthetic hormones in contraception are synthetically manufactured and difficult for the body to metabolize. For the body to metabolize the synthetic hormones, it causes a depletion of essential nutrients B6, B9, B12, Zinc and Magnesium, Vitamin C, E and essential fatty acids. Dr. Butterworth also notes that it’s these very nutrients that are needed to maintain a healthy hormonal system. He also said that “Women with chronic hormonal conditions, like Premenstrual Dysphoric Disorder (PMDD), Endometriosis and Polycystic Ovarian Syndrome (PCOS), often have an underlying genetic inability to metabolize hormones. When additional synthetic hormones are then added into their system, these synthetic hormones literally become a poison for these women.” The article also lists risk factors of taking synthetic hormones, they are:
The post also outlines less serious, yet life-disrupting symptoms such as; weight gain, migraines, fungal infections (Candida), vaginal discharges (thrush), breast cysts, fibrocystic breast disease, tender breasts, high blood pressure, increased cholesterol, breakthrough bleeding, fluid retention, acne, mouth ulcers, hair loss, facial and body hair, varicose veins, liver function disruption, psychological and emotional disorders. https://happyhealthyyou.com/blogs/articles/dangers-of-synthetic-hormones Progestins MedicalNewsToday says this about Progestins: “Progesterone occurs naturally in the body, but laboratories can also produce it. Synthetic steroid hormones with progesterone-like properties are called progestins. Progestin side effects include: headaches, breast tenderness or pain, upset stomach, vomiting, diarrhea, constipation, changes in appetite, weight gain, fluid retention, tiredness, muscle/ joint/bone pain, mood swings and irritability, excessive worrying, runny nose, sneezing, cough, vaginal discharge and problems urinating.” They also list potentially serious side effects requiring medical attention as: “breast lumps, dimpling of breast skin, clear or bloody discharge from nipple, inverted nipple, crusting or scaling of the nipple, clay-colored stools, migraine headache, severe dizziness, slow speech or difficulty speaking, weakness or numbness of limbs, absence of coordination, breathlessness, pounding heartbeat, sharp chest pain, coughing up blood, leg swelling, loss of or blurred vision, bulging eyes, double vision, unexpected vaginal bleeding, uncontrollable shaking hands, seizures, stomach pain or swelling, depression, hives, skin rash, itching, difficulty swallowing, swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs, hoarseness.” https://www.medicalnewstoday.com/articles/277737#progestin-progesterone-in-medication Antigonadotropin Wikipedia described an antigonadotropin as “a drug which suppresses the activity and/or downstream effects of one or both of the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH). This results in an inhibition of the hypothalamic-pituitary-gonadal (HPG) axis, and thus a decrease in the levels of the androgen, estrogen and progestogen sex steroids in the body… High-dose antigonadotropin therapy has been referred to as medical castration… Since progestins have relatively little effect on sexual differentiation compared to the other sex steroids, potent ones such as medroxyprogesterone acetate is often used at high doses specifically for their antigonadotropic effects.” https://en.wikipedia.org/wiki/Antigonadotropin Steroidal Antiandrogen Wikipedia explains: “A steroidal antiandrogen (SAA) is an antiandrogen with a steroidal chemical structure. Antiandrogens, also known as androgen antagonists or testosterone blockers, are a class of drugs that prevent androgens like testosterone and dihydrotestosterone (DHT) from mediating their biological effects in the body. They act by blocking the androgen receptor (AR) and/or inhibiting or suppressing androgen production." https://en.wikipedia.org/wiki/Steroidal_antiandrogen Medroxyprogesterone Acetate Medroxyprogesterone Acetate, also known as MPA is the main ingredient in the Depo shot. MPA inhibits the production of gonadotropins (luteinizing hormone (LH) and follicle-stimulating hormone (FSH) hormones) and in effect, by suppressing all sex hormone levels, it prevents ovulation which is how it prevents pregnancy. By inhibiting the production of these hormones though, it also thins the endometrium which is the mucous membrane lining of the uterus. MPA suppresses hypothalamic–pituitary–adrenal (HPA) and hypothalamic–pituitary–gonadal (HPG) axes which ultimately results in decreased levels of not only gonadotropins, but also androgens, estrogens, adrenocorticotropic hormone (ACTH) and cortisol. Suppressing hormones like this can have consequences, not only with unpleasant side effects but subsequent long term damage to the body. Many women have never been able to produce certain sex hormones again after Depo-suppression. Many women also struggle with hypothalamic–pituitary–adrenal (HPA axis) issues after Depo-suppression. Sometimes the body just can’t bounce back after being forcibly shut down. Common side effects of MPA include menstrual disturbances such as absence of periods, abdominal pain, headaches, bone loss, blood clots, allergic reactions and liver problems. Medroxyprogesterone may also increase the risk of uterine or ovarian cancer in some women and may also increase the risk of heart disease, breast cancer and dementia. MPA also has glucocorticoid activity in the body which means that it turns your immune system down – essentially suppressing that too. The PubChem National Library of Medicine GHS Hazard Statements states the following about Medroxyprogesterone Acetate: H302 (13.84%): Harmful if swallowed [Warning Acute toxicity, oral], H312 (13.84%): Harmful in contact with skin [Warning Acute toxicity, dermal], H332 (13.39%): Harmful if inhaled [Warning Acute toxicity, inhalation], H351 (99.55%): Suspected of causing cancer [Warning Carcinogenicity], H360 (40.62%): May damage fertility or the unborn child [Danger Reproductive toxicity], H362 (11.61%): May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation], H413 (12.5%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]. Medroxyprogesterone Acetate is listed as an IRRITANT and a HEALTH HAZARD. Its safety signal is WARNING and DANGER. Take a look for yourself. https://pubchem.ncbi.nlm.nih.gov/compound/6279 SIDE NOTE In California, they have what they call Proposition 65. It requires businesses to provide warnings to residents of California about significant exposures to chemicals that cause cancer, birth defects and other reproductive harm. Medroxyprogesterone Acetate is listed as causing Cancer and Reproductive Toxicity. https://www.p65warnings.ca.gov/chemicals/medroxyprogesterone-acetate Polyethylene Glycol 3350 Amount 28.9 mg Drug Class Osmotic Laxative Chemical Safety IRRITANT Safety Signal WARNING Drug Class Breakdown Osmotic Laxatives Merriam Webster explains “the definition of osmotic: of, relating to, caused by, or having the properties of osmosis.” Osmosis: “1: movement of a solvent (such as water) through a semipermeable membrane (as of a living cell) into a solution of higher solute concentration that tends to equalize the concentrations of solute on the two sides of the membrane 2: a process of absorption or diffusion suggestive of the flow of osmotic action.” https://www.merriam-webster.com/dictionary/osmotic Laxatives are substances that either loosen stool or stimulate a bowel movement, they can also accelerate intestinal passage which essentially speeds up the movement of the digestive tract. Polyethylene Glycol 3350 Polyethylene glycol 3350 is a laxative solution that works by increasing the amount of water in the intestinal tract to stimulate bowel movements. It’s noted that you shouldn’t use Polyethylene glycol 3350 if you are allergic to it or if you have a bowel obstruction and or intestinal blockage. Subsequently, if you do have any of these conditions and use Polyethylene glycol 3350 you could experience dangerous or life-threatening side effects. People with eating disorders like anorexia or bulimia are also cautioned not use Polyethylene glycol 3350. Side effects include but are not limited to: severe or bloody diarrhea, rectal bleeding, blood in stools, severe stomach pain, bloating, gas, dizziness, hives and increased sweating. Potential life-threatening hypersensitivity is also a risk of using Polyethylene glycol. Polyethylene glycol is listed as an IRRITANT. Its safety signal is WARNING. Take a look for yourself: https://pubchem.ncbi.nlm.nih.gov/compound/174  Polysorbate 80 Amount 2.41 mg Drug Class Nonionic Surfactant Chemical Safety IRRITANT, FLAMMABLE Safety Signal NO INFORMATION FOUND Drug Class Breakdown Nonionic Surfactant Surfactants are compounds that lower the surface tension between either two liquids, a gas and a liquid, or a liquid and a solid. Surfactants can sometimes act as detergents, wetting agents, emulsifiers, foaming agents or dispersants. From a Depo shot perspective, it’s used an emulsifier/stabilizer. It basically takes the contents of what would be like oil and water and allows them to mix together seamlessly. Polysorbate 80 Polysorbate 80, also known as Tween is known to cause damage on a cellular level. Polysorbate 80 use can cause cell “permeability, damage and bursting.” Studies also show that it can break down into sorbitol and ethylene oxide in the body which comes with its own slew of risks. (Diabetes, cell death, mitochondrial failure, DNA fragmentation) Injected Polysorbate 80 has also been shown to abruptly change heart function. Vaccine Choice Canada wrote “Clinical studies have shown that Polysorbate 80 increases the risk of serious side effects like blood clots, stroke, heart attack, heart failure, and even death in some cases. It has also been shown to shorten overall survival and/or increase the risk of tumor growth or recurrence in patients with certain types of cancer.” Truthsnitch.com shared that “a study published in the American Academy of Cancer Research found that a diet including regular consumption of emulsifiers experienced exacerbated tumor development and chronic low-level inflammation. This chronic inflammation was also associated with inflammatory bowel diseases like Crohn’s and is observed in colorectal cancers. The study also points out that occurrence of colorectal cancers have been markedly increasing since the mid-20th century.” https://cancerres.aacrjournals.org/content/77/1/27 They also mention the “2015 study also linked Polysorbate 80 to gut inflammation and how it negatively altered gut bacteria, obesity and metabolic syndromes.” https://pubmed.ncbi.nlm.nih.gov/25731162/ Truthsnitch.com goes on to say that “Polysorbate 80 has been linked to infertility. A study shows that baby female rates were injected with Polysorbate 80 at days 4-7 after birth which resulted in their accelerated maturation, caused changes to the vagina and womb lining, hormonal changes, ovary deformities and degenerative follicles.” https://pubmed.ncbi.nlm.nih.gov/8473002/ Injected Polysorbate 80 has been identified as a cause of anaphylaxis. Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death. Truthsnitch.com said “The study, Anaphylaxis Due to the Excipient Polysorbate 80, appeared in the Annals of Allergy, Asthma and Immunology in December of 2005. (Page 21) “In our conclusion, based on our results and the literature reviewed, we believe that Polysorbate 80 should be included in the test battery for allergy to medications such as corticosteroids, since it could be a cause of anaphylaxis of unknown etiology.” http://www.jiaci.org/revistas/vol26issue6_5_10.pdf The National Library of Medicine notes that “Polysorbate 80 is a ubiquitously used solubilizing agent that can cause severe nonimmunologic anaphylactoid reactions.” https://pubmed.ncbi.nlm.nih.gov/16400901/ Nature.com posted about a study that has shown a connection between Polysorbate 80 and the development of bowel problems. https://www.nature.com/articles/nature14232 A BMJ Journal article noted that Polysorbate 80, induced low-grade inflammation and obesity/metabolic syndrome and promoted robust colitis in mice predisposed to the condition. They also suggest that the use of emulsifying agents may be contributing to an increased societal incidence of obesity/metabolic syndrome and other chronic inflammatory diseases. BMJ Journal wrote about Polysorbate 80’s ability to exacerbate Crohn’s Disease. https://gut.bmj.com/content/59/10/1331.full Polysorbate 80 has also been linked with an increased risk of blood clots, stroke, heart attack, heart failure and of tumor growth or recurrence in patients with certain types of cancer. The Good Human shared the Material Safety Data Sheet for Polysorbate 80 • Slightly flammable to flammable in presence of heat • Slightly hazardous in case of skin/eye contact (irritant), eye contact, ingestion, inhalation. • May cause adverse reproductive effects based on animal test data. No human data found. • May cause cancer based on animal test data. No human data found. • May affect genetic material (mutagenic) https://thegoodhuman.com/what-is-polysorbate-80/ Polysorbate 80 is listed as an IRRITANT and FLAMMABLE. Take a look for yourself. https://en.wikipedia.org/wiki/Polysorbate_80 Sodium Chloride Amount 8.68 mg Drug Class Ionic Compound Chemical Safety IRRITANT Safety Signal WARNING Drug Class Breakdown Ionic Compound The Chemical Dictionary explains that an “ionic compounds are compounds consisting of ions. Two-element compounds are usually ionic when one element is a metal and the other is a non- metal.” https://www.chemicool.com/definition/ionic-compounds.html Sodium Chloride Sodium chloride is the chemical name for salt. No, no not like in your salt shaker. Sodium chloride is widely used and has many different applications. It plays an important part in nerve impulses and muscle contractions and it also helps regulates the amount of water in your body. Sodium chloride is sometimes used to treat or prevent sodium loss caused by dehydration and or excessive sweating. Drugs.com says “you should not take sodium chloride if you have ever had an allergic reaction to it, or if you have high sodium levels in your blood. Before you take sodium chloride, tell your doctor if you have high blood pressure, kidney or liver disease, fluid retention (especially around your legs or your lungs), congestive heart failure, preeclampsia of pregnancy if you are on a low-salt diet, or if you are allergic to any foods or drugs. Stop using sodium chloride and call your doctor at once if you have stomach pain, nausea and vomiting, or swelling in your hands or feet.” Side effects are listed as “nausea and vomiting, stomach pain or swelling in your hands, ankles, or feet.” Sodium chloride’s chemical safety is listed as an IRRITANT. Its safety signal is WARNING. Take a look for yourself. https://pubchem.ncbi.nlm.nih.gov/compound/Sodium-chloride Methlparaben Amount 1.37 mg Drug Class Parabens Chemical Safety IRRITANT Safety Signal WARNING Drug Class Breakdown Parabens Parabens are hugely controversial. The controversy stems over the estrogenic potential and possible reproductive toxicity. ResearchGate says “Parabens are used as preservatives in food, cosmetic and pharmaceutical products. Some animal studies have reported adverse reproductive effects of parabens. In an uterotrophic assay, methyl and butyl paraben administered orally to immature rats were inactive, while subcutaneous administration of butyl paraben produced a weak positive response. The ability of parabens to transactivate the estrogen receptor in vitro increases with alkyl group size. The detection of parabens in a small number of breast tumor tissue samples and adverse reproductive effects of parabens in animals has provoked controversy over the continued use of these substances.” https://www.researchgate.net/publication/7904546_Safety_assessment_of_esters_of_p-hydroxybenzoic_acid_Parabens Paraben.co.uk explains that “Parabens are used to make products last longer; their chemical properties make them effective preservatives that keep ingredients fresher for longer. These preservatives kill molds and funguses before they have a chance to spread and damage products. While the “pros” of using Parabens are few, they do dramatically extend the shelf life and efficacy of many beauty and health care items; they keep products from spoiling on store shelves or going bad in home medicine cabinets.” “According to certain Paraben studies, these chemicals (which include methylparaben, ethylparaben, propylparaben, butylparaben and isobutylparaben, among others) may harm human health by contributing to the development of cancerous tumors. While there are differing views on this subject from a range of medical researchers, there is little question that these chemicals are found in some cancerous tumor tissue. The links between Parabens and cancer (specifically breast cancer) is of particular concern to many people. Since Parabens are commonly present in many items that are specifically marketed to females (such as makeup items, cleansers, and shampoos), many females are appalled to learn that they have been putting Parabens on (and in) their bodies for years. Women with breast cancer in their family medical histories may be particularly determined to learn what Parabens are, and to eliminate potentially harmful Parabens from their beauty kits, shower stalls, and medicine cabinets. The presence of Parabens in some breast cancer tumors is undeniable; however, the role that these chemicals play (if any) in the development of breast cancer – or any other harmful diseases – is still hotly debated.” https://www.paraben.co.uk/ Parabens are classified as a group of endocrine disrupting chemicals (EDCs). EDCs are defined as exogenous chemicals or a mixture of chemicals that can interfere with any aspect of hormone action. (Zoeller et al., 2012) – Lifestyle Medicine (Third Edition), 2017 Here's more information on Parabens and interference with the endocrine system: Parabens Interfere in the Functioning of Endocrine Organs https://www.sciencedirect.com/science/article/abs/pii/S0303720718301060 Effects of Endocrine Disrupters on Immune Function and Inflammation Endocrine-disrupting chemicals (EDCs) are among the most hazardous toxicants known. They can affect immune function directly… https://www.sciencedirect.com/science/article/pii/B9780128011393000144 Endocrine Disruption in Wildlife Species https://www.sciencedirect.com/science/article/pii/B9780123820327100839 Transgenerational Epigenetics of Endocrine-Disrupting Chemicals https://www.sciencedirect.com/science/article/pii/B9780124059443000180 Endocrine Disrupting Chemicals and Behavior https://www.sciencedirect.com/science/article/pii/B9780128012383651917 Environmental Endocrine Disruption of Brain and Behavior https://www.sciencedirect.com/science/article/pii/B9780128035924000948 Parabens can enable hallmarks and characteristics of cancer in human breast epithelial cells: a review of the literature with reference to new exposure data and regulatory status. https://onlinelibrary.wiley.com/doi/abs/10.1002/jat.3027 Maternal paraben exposure triggers childhood overweight development https://www.nature.com/articles/s41467-019-14202-1 Methylparaben Methylparaben belongs to the paraben family. Researchers are starting to look at whether the use of methylparabens and other parabens together, is safe. To date, there is no evidence either way. Remember that the Depo shot has both Methylparaben and Propylparaben in it so this’s definitely concerning. Hang on though, it gets worse. Wikipedia says that “Methylparaben is an anti-fungal agent often used in a variety of cosmetics and personal-care products.” Generally Methylparaben is used as a fungicide. Methylparaben is noted toxic at higher concentrations. It’s also known that it has an estrogenic effect and anti-androgenic activity in the body. Healthline.com notes that “A similar study suggested that skin damage from exposure to sunlight while using a product containing methylparaben might lead to the formation of cancer. This may be due to the oxidative DNA damage that it could cause.” They also said “Studies indicate that methylparaben applied on the skin may react with UVB, leading to increased skin aging and DNA damage.” Methylparaben’s chemical safety is listed as an IRRITANT. Its safety signal is WARNING. Take a look for yourself. https://pubchem.ncbi.nlm.nih.gov/compound/7456 Propylparaben Amount 0.150 mg Drug Class Parabens Chemical Safety IRRITANT Safety Signal WARNING The drug class breakdown is the same as Methylparaben, see above under Parabens. Propylparaben has been used as an antimicrobial preservative in the food, cosmetic and pharmaceutical industries for many, many years. Just like Methylparaben, Propylparaben is also controversial. From everything that I’ve been reading while researching for this post, the two are often used together. Scientists are just now starting to look at whether combining these parabens is safe. Presently there is not conclusive evidence either way. Scary right? Toxicity data on NIH’s PUBCHEM site shows skin and eye irritations, DNA ovary damage and DNA kidney damage due to Propylparaben. In the Encyclopedia of Food Microbiology (Second Edition), 2014 they said this about Propylparabens: “Propylparabens had effects on sperm production at a relatively low dose in male juvenile rats.” EWG says “Parabens can act like the hormone estrogen in the body and disrupt the normal function of hormone systems affecting male and female reproductive system functioning, reproductive development, fertility and birth outcomes. Parabens can also interfere with the production of hormones.” Propylparaben’s chemical safety is noted as an IRRITANT. Its safety signal is WARNING. Take a look for yourself. https://pubchem.ncbi.nlm.nih.gov/compound/Propylparaben Water Amount “quantity sufficient” – whatever that means but its water, so let’s move on. Just when you think that it can’t get any worse… in what kind of feels like an “oh by the way” – there are two more ingredients that may or may not be included in each injection vial. FDA product information says “When necessary, pH is adjusted with sodium hydroxide or hydrochloric acid, or both.” This means that these two substances, at undisclosed amounts may or may not be in the shot that you took. Let’s take a look at Sodium Hydroxide and Hydrochloric Acid. Sodium Hydroxide Amount Undisclosed Drug Class Inorganic Compound, Alkali Metal Hydroxides Chemical Safety CORROSIVE Safety Signal DANGER Drug Class Breakdown Alkali Metal Hydroxides This just keeps getting worse. Wikipedia says this about alkali metal hydroxides: “All alkali metal hydroxides are strong bases, meaning that they dissociate completely in solution to give ions. As strong bases, alkali hydroxides are highly corrosive and are used in cleaning products.” https://en.wikipedia.org/wiki/Alkali_hydroxide Encyclopedia Britannica explains “The hydroxides include the familiar alkalies of the laboratory and industrial processes. The hydroxides of the alkali metals, lithium, sodium, potassium, rubidium, and cesium, are the strongest bases and the most stable and most soluble of the hydroxides. Sodium hydroxide, NaOH, also known as caustic soda or lye, is of great industrial importance. Calcium, barium, and strontium—all alkaline earth metals—form soluble hydroxides that are strong bases but are less stable than the alkali hydroxides.” https://www.britannica.com/science/hydroxide Sodium Hydroxide Sodium hydroxide is corrosive and flagged as dangerous. NIH’s PUBCHEM says “Contact may severely irritate skin, eyes, and mucous membranes. Toxic by ingestion. Corrosive to metals and tissue.” https://pubchem.ncbi.nlm.nih.gov/compound/14798 DRUGBANK warns “Human poisoning cases indicate that a dose of 10 grams orally is fatal. Sodium hydroxide is toxic by oral ingestion. Sodium hydroxide is corrosive to all tissues. Concentrated vapors lead to serious damage to the eyes and respiratory system. Oral ingestion of sodium hydroxide causes severe tissue necrosis, with stricture formation of the esophagus, often resulting in death. Contact with the skin may result in contact dermatitis, hair loss, as well as necrosis due to severe irritation. Increased incidence of esophageal carcinoma after severe intoxication with sodium hydroxide has been reported in man. In animal studies, long-term dermal contact with substances leading to pH changes in the skin causes the development of tumors, as a result of severe tissue irritation and reparative cell growth. May cause damage to the following organs: mucous membranes, upper respiratory tract, skin and eyes. Because of its high-level alkalinity, sodium hydroxide in aqueous solution directly causes bond breakage in proteins. Hair and fingernails are found to be dissolved after 20 hours of direct contact with sodium hydroxide.” https://go.drugbank.com/drugs/DB11151 The National Fire Protection Association (NFPA) hazard classification diamond consists of four colour- coded cubes: blue, red, yellow and white. The blue, red, and yellow cubes represent health hazard, flammability and reactivity by using a numbering scale ranging from 0 to 4. Sodium hydroxide is a 3 for health hazard which is described as “materials that, under emergency conditions, can cause serious or permanent injury.” Adding to it, under the subtitle Health Hazards it states:
And under the subtitle Hazards Summary is reads:
https://pubchem.ncbi.nlm.nih.gov/compound/14798 Last and perhaps the worst of them all… Hydrochloric Acid. Hydrochloric Acid Amount Undisclosed Drug Class Muriatic Acid Chemical Safety CORROSIVE, ACUTE TOXIC Safety Signal DANGER Drug Class Breakdown Muriatic Acid Chemistry Expert, Anne Marie Helmenstine, Ph.D explains Muriatic Acid as “one of the names for hydrochloric acid, a corrosive strong acid. It is also known as spirits of salt or acidum salis. "Muriatic" means "pertaining to brine or salt.” Hydrochloric acid has many uses. Here are a few that I found in my quest for information: neutralization of alkaline agents, it’s also bleaching agent in the synthesis of dyes and chemicals and in metal refining. If that wasn’t bad enough – it’s also used in the production of chlorides, fertilizers, electroplating and in the photographic, textile, and rubber industries. Yikes! Hydrochloric acid is corrosive to the eyes, skin, and mucous membranes. Short term inhalation exposure is said to may cause eye, nose and respiratory tract irritation and inflammation and possibly pulmonary edema. Short term oral exposure may cause corrosion of the mucous membranes, esophagus, and stomach and dermal contact may produce severe burns, ulceration, and scarring. Long term occupational exposure to hydrochloric acid has been reported to cause gastritis, chronic bronchitis, dermatitis and photosensitization. Prolonged exposure to low concentrations is said to may cause dental discoloration and erosion. Hydrochloric acid or muriatic acid is described as a colorless solution with a really disgusting and distinctive, pungent smell. Hydrochloric acid is classified as a strong acid, it’s known to be corrosive to living tissues and many man-made materials. Hydrochloric acid warnings are serious. Chemical safety is CORROSIVE and ACUTE TOXIC. The safety signal is DANGER. Take a look for yourself. https://pubchem.ncbi.nlm.nih.gov/compound/Hydrochloric-acid And there you have it - combining Medroxyprogesterone acetate, Polyethylene glycol 3350, Polysorbate 80, Sodium chloride, Methylparaben, Propylparaben, Water and “when necessary” undisclosed amounts of Sodium Hydroxide and or Hydrochloric Acid makes up a Depo shot. How terrifying when you break it all down in plain language! Here’s a recap for easy reference.  Why are the Depo shot risks so vastly noted yet unnoticed? For the last eleven years, I’ve wondered how something so dangerous could escape public uproar and that it’s continuingly pushed despite so many women suffering its effects. After writing this piece, I’m more baffled than ever. We’ve gone over the basics on each of Depo’s ingredients and as we’ve seen – each of them have their own concerns, risks, side effects and warnings. You decide. Is the Depo shot safe? Resources & References Medroxyprogesterone Acetate National Library of Medicine PUBCHEM https://pubchem.ncbi.nlm.nih.gov/compound/Medroxyprogesterone-acetate Proposition 65 Warnings https://www.p65warnings.ca.gov/chemicals/medroxyprogesterone-acetate Wikipedia https://en.wikipedia.org/wiki/Medroxyprogesterone_acetate Drugs.com https://www.drugs.com/medroxyprogesterone.html Polyethylene Glycol 3350 Drugs.com https://www.drugs.com/mtm/polyethylene-glycol-3350.html PUBCHEM https://pubchem.ncbi.nlm.nih.gov/compound/174 MedlinePlus https://medlineplus.gov/druginfo/meds/a603032.html BIOMEDCENTRAL https://aacijournal.biomedcentral.com/articles/10.1186/s13223-016-0172-7 Polysorbate 80 Vaccine Choice Canada https://vaccinechoicecanada.com/health-risks/anaphylaxis-allergies-asthma/polysorbate-80-risks-2/ AACR Journals https://cancerres.aacrjournals.org/content/77/1/27 PUBMED https://pubmed.ncbi.nlm.nih.gov/25731162/ PUBMED https://pubmed.ncbi.nlm.nih.gov/8473002/ PUBMED https://pubmed.ncbi.nlm.nih.gov/16400901/ PRACTITIONER'S CORNER http://www.jiaci.org/revistas/vol26issue6_5_10.pdf Nature.com https://www.nature.com/articles/nature14232 BMJ Journal https://gut.bmj.com/content/59/10/1331.full The Good Human https://thegoodhuman.com/what-is-polysorbate-80/ Sodium Chloride Drugs.com https://www.drugs.com/mtm/sodium-chloride-oral.html#:~:text=Sodium%20chloride%20is%20the%20chemical,excessive%20sweating%2C%20or%20other%20causes. Chemical Dictionary https://www.chemicool.com/definition/ionic-compounds.html PUBCHEM https://pubchem.ncbi.nlm.nih.gov/compound/Sodium-chloride Parabens Paraben UK https://www.paraben.co.uk/ ResearchGate https://www.researchgate.net/publication/7904546_Safety_assessment_of_esters_of_p-hydroxybenzoic_acid_Parabens Health Controversies Parabens https://www.grimalt.net/wp-content/uploads/2013/04/parabens-2013.pdf Parabens and their effects on the endocrine system https://www.sciencedirect.com/science/article/abs/pii/S0303720718301060 Methylparaben DRUGBANK https://go.drugbank.com/drugs/DB14212 Wikipedia https://en.wikipedia.org/wiki/Methylparaben PUBCHEM https://pubchem.ncbi.nlm.nih.gov/compound/7456 Propylparaben EWG https://www.ewg.org/californiacosmetics/parabens#:~:text=The%20concern%20with%20these%20chemicals,can%20also%20cause%20skin%20irritation. Sodium Hydroxide DRUGBANK https://go.drugbank.com/drugs/DB11151 Hydrochloric Acid PUBCHEM https://pubchem.ncbi.nlm.nih.gov/compound/Hydrochloric-acid Science Direct https://www.sciencedirect.com/science/article/pii/B0123694000004981 ThoughtCo https://www.thoughtco.com/what-is-muriatic-acid-608510#:~:text=Muriatic%20acid%20is%20one%20of,available%20at%20home%20supply%20stores. Additional The Center for Disease Control and Prevention https://www.cdc.gov/niosh/topics/hazdrug/antineoplastic.html Happy Healthy You https://happyhealthyyou.com/blogs/articles/dangers-of-synthetic-hormones Medical News Today https://www.medicalnewstoday.com/articles/277737#progestin-progesterone-in-medication Wikipedia https://en.wikipedia.org/wiki/Antigonadotropin https://en.wikipedia.org/wiki/Steroidal_antiandrogen Proposition 65 https://www.p65warnings.ca.gov/chemicals/medroxyprogesterone-acetate American Association for Cancer Research – AACR Journals https://cancerres.aacrjournals.org/content/77/1/27 Merriam Webster https://www.merriam-webster.com/dictionary/osmotic Nature.com https://www.nature.com/articles/nature14232
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